Science at the Edge Seminar
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Speaker: Karen Guillemin, Department of Biology, Institute of Molecular Biology, University of Oregon
Title: “Teaming with Microbes: Lessons from the Zebrafish Intestine”
Refreshments at 11:15 am.
Date: Fri, 27 Apr 2018, 11:30 am – 12:30 pm
Location: 1400 BPS Bldg.
(Originally scheduled for March 2nd)
Microbial colonization of the digestive tract is a crucial event in vertebrate development, required for maturation of host immunity and establishment of normal digestive physiology. We have developed gnotobiotic zebrafish as a model system to study how intestinal microbial communities are established, how they influence host development, and how perturbations of the microbiota can result in loss of intestinal homeostasis and inflammation. Using defined microbial communities that we can visualize with light sheet microscopy, we are exploring bacterial colonization dynamics of the intestine. We are also using bacterial genetic approaches to identify bacterial factors that influence host programs of intestinal epithelial renewal and innate immune system maturation. Finally, we make use of zebrafish genetics and transgenesis to explore the host pathways that perceive and respond to bacterial factors that influence intestinal homeostasis.